MOTS-C

MOTS-c is a synthetic 16-residue peptide whose sequence corresponds to a mitochondrial-derived peptide, an open reading frame encoded within the mitochondrial genome rather than in nuclear DNA. It belongs to a small family of short sequences read from mitochondrial DNA and studied in mitochondrial biology, cellular bioenergetics and metabolic research. The catalogue files it under cell biology, records no synonyms, and lists 10 mg and 40 mg vials of lyophilized powder.

In single-letter notation the sequence is written MRWQEMGYIFYPRKLR: two methionines, three basic residues towards the C terminus, and an aromatic set of one tryptophan and two tyrosines that makes ultraviolet absorbance at 280 nm a practical concentration check. It is catalogued under CAS 1627580-64-6 with the molecular formula C101H152N28O22S2 and a molecular weight of 2174.60 g/mol, and the two sulfur atoms in that formula match the two methionine residues in the sequence.

Lyophilized material is held at -20 C protected from light, and reconstituted solution at 2 to 8 C for short-term laboratory use, with repeated freeze-thaw cycling avoided and methionine oxidation worth guarding against. Purity and identity are verified by third-party HPLC and mass spectrometry, with a certificate of analysis per lot. This material is supplied strictly for laboratory research and is not for human or veterinary use.