Cell Biology
Vilon
Synthetic Dipeptide Research Material for Gene Expression & Cellular Signaling Studies
Vilon is a synthetic dipeptide research material composed of the amino acids L-lysine and L-glutamic acid (L-Lys-L-Glu). Also referred to in the scientific literature as the KE peptide, Vilon has been investigated in laboratory models involving gene regulation, cellular signaling, immune-cell activity, and proliferative processes. Experimental studies have examined the influence of the Lys-Glu peptide on gene-expression pathways, including interleukin-2 expression in lymphocytes and expression of cellular regulatory proteins such as SIRT1, PARP1, and PARP2. Vilon has also been studied in vitro for its effects on inflammatory and proliferative processes in human monocytic cell models, making it of interest for controlled investigations of short-peptide signaling, transcriptional regulation, and cellular response mechanisms. For laboratory research use only. Not for human or veterinary use. Not for consumption, administration, diagnostic use, or therapeutic use.
Frequently researched together
Other laboratory research compounds available in our catalog.
Compound information
Technical specifications
What is Vilon?
Vilon is a synthetic 2-residue peptide whose sequence corresponds to the dipeptide L-lysine and L-glutamic acid, written Lys-Glu. In the single-letter amino-acid code that reads as KE, which is why the research literature commonly calls it the KE peptide. The catalogue lists it in the cell-biology section and records no other catalogue synonyms.
The compound belongs to the group of very short synthetic peptides described as peptide bioregulators, a class defined in the Russian-language gerontology literature and studied there as a family rather than one molecule at a time. The sequence is linear, with a free N-terminal amine on the lysine residue and a free C-terminal carboxyl on the glutamic-acid residue, and no acetylation, amidation or D-amino acid substitution is recorded. One basic side chain and one acidic side chain leave the dipeptide zwitterionic across most of the ordinary buffer range, and at two residues it has no secondary structure.
The catalogue entry records no numerical identifiers: a CAS registry number, a molecular formula and a molecular weight are each not catalogued here, so none is stated. The material is supplied lyophilized in a 20 mg vial. Purity and identity are established by third-party HPLC and mass spectrometry, with a certificate of analysis for each lot. Vilon is supplied strictly for laboratory research and is not for human or veterinary use, nor for consumption, administration, diagnostic use or therapeutic use.
Stability information
Recommended handling and storage conditions for retaining compound identity and integrity in the laboratory.
Store lyophilized at −20°C, protected from light. Reconstitute and refrigerate (2–8°C) for short-term research use.
Regulatory information
Development origin and regulatory status, compiled for reference.
Research compound · Not FDA-approved
Frequently asked
Questions about Vilon
What purity is Vilon supplied at, and is a Certificate of Analysis available?
Yes. Each lot of Vilon is tested by a third-party laboratory using HPLC for purity, and the certificate of analysis for the current lot is linked on this page and in the certificate library.
How is the identity of Vilon verified?
Identity is confirmed by mass spectrometry against the expected molecular weight, alongside HPLC retention behaviour. Both results are recorded on the lot certificate.
How should Vilon be stored on receipt?
Lyophilized material is stored at -20 C protected from light. Once reconstituted it is kept at 2 to 8 C for short-term laboratory use, and repeated freeze-thaw cycles are avoided.
Where is Vilon shipped from?
Orders ship from the United States in discreet, tracked packaging. Shipping is available to US addresses only.
Is Vilon supplied for research use only?
Yes. Vilon is sold strictly as a laboratory research material. It is not for human or veterinary use, not for diagnostic procedures, and has not been evaluated by the U.S. Food and Drug Administration. See the research use disclaimer for the full terms.
Answers describe how this material is tested, stored and shipped. They are not guidance on any use, and this compound is not for human or veterinary use.
Sources & references
Published literature in which this compound has been the subject of laboratory or preclinical study. Listed for bibliographic reference only.
Research and educational purposes only. These references are provided for bibliographic context. They are not evidence of safety or efficacy, and nothing here is medical advice or a claim about any use in humans or animals.
Bulletin of experimental biology and medicine
Effect of vilon on biological age and lifespan in mice
Bulletin of experimental biology and medicine
Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology
Bulletin of experimental biology and medicine
Effect of vilon and epithalon on activity of enzymes in epithelial and subepithelial layers in small intestine of old rats
Advances in gerontology = Uspekhi gerontologii
[Combined effect of vilon and cyclophosphane on tumor transplants and lymphoid tissue explants in mice and rats of various age]
Biogerontology
Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people